Abstract | PURPOSE: Recently, a proteomic study of sera from patients with bladder cancer identified S100A8 and S100A9 as tumor-associated proteins. The present cross-sectional study investigates whether calprotectin, the heterodimer of S100A8/S100A9 may serve as a urinary biomarker for the detection of urothelial bladder cancer. METHODS: RESULTS: Median calprotectin concentrations (ng/ml) were significantly higher in patients with bladder cancer than in healthy controls (522.3 vs. 51.0, p < 0.001), renal cell cancer (90.4, p < 0.001), and prostate cancer (71.8, p < 0.001). In urothelial carcinoma prominent immunostaining occurred in a subset of tumor cells and in infiltrating myeloid cells. Receiver operating characteristic analysis provided an area under the curve of 0.88 for the differentiation of bladder cancer and healthy control. A cut-off value of 140 ng/ml (determined by Youden's index) resulted in sensitivity and specificity values of 80.4 and 92.5 %. Low grade tumors were associated with significantly lower calprotectin concentrations than high grade tumors (351.9 vs. 1635.2 ng/ml, p = 0.004). CONCLUSIONS:
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Authors | Jan Ebbing, Susanne Mathia, Felix S Seibert, Nikolaos Pagonas, Frederic Bauer, Barbara Erber, Karsten Günzel, Ergin Kilic, Carsten Kempkensteffen, Kurt Miller, Alexander Bachmann, Christian Rosenberger, Walter Zidek, Timm H Westhoff |
Journal | World journal of urology
(World J Urol)
Vol. 32
Issue 6
Pg. 1485-92
(Dec 2014)
ISSN: 1433-8726 [Electronic] Germany |
PMID | 24378824
(Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Leukocyte L1 Antigen Complex
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Topics |
- Aged
- Biomarkers, Tumor
(urine)
- Carcinoma
(diagnosis, urine)
- Cross-Sectional Studies
- Female
- Humans
- Kidney Neoplasms
(urine)
- Leukocyte L1 Antigen Complex
(urine)
- Male
- Middle Aged
- Predictive Value of Tests
- Prostatic Neoplasms
(urine)
- ROC Curve
- Urinary Bladder Neoplasms
(diagnosis, urine)
- Urothelium
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