CYP1A1 genetic polymorphisms and risk for esophageal cancer: a case-control study in central China.

Abstract

The purpose of this study was to evaluate the associations of CYP1A1 genetic polymorphisms with the risk of developing esophageal cancer (EC). A case-control study was carried out in a Chinese population in which 157 hospital based EC cases and 157 population based healthy controls with 1:1 match by age and sex were included. PCR based restriction fragment length polymorphisms (PCR-RFLP) were used to detect genotypes in case and control groups. For the CYP1A1 Ile/Val polymorphism, comparing with wild genotype Ile/Ile, both the heterozygote genotype Ile/Val and the combined variant genotype Ile/Val+Val/Val increased the risk of esophageal cancer (OR: 2.05, 95%CI: 1.19-3.54, OR: 1.86, 95%CI: 1.11-3.12). No significant association was found between the CYP1A1 MspI polymorphism and EC. According to analysis of combined genotypes, the TC/AG combined genotype which contained both variant alleles of these two polymorphisms increased the risk of developing EC (OR: 2.12, 95%CI: 1.16-3.85). Our results suggested that genetic polymorphisms of CYP1A1 may increase the susceptibility to EC.

• Authors: Yu-Xia Yun, Yan-Ping Wang, Peng Wang, Li-Hong Cui, Kai-Juan Wang, Jian-Ying Zhang, Li-Ping Dai
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 11 Pg. 6507-12 (Jan 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 24377558 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CYP1A1 protein, human
• Cytochrome P-450 CYP1A1

Topics

• Case-Control Studies
• China
• Cytochrome P-450 CYP1A1 (genetics)
• Esophageal Neoplasms (genetics)
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Polymerase Chain Reaction
• Polymorphism, Genetic (genetics)
• Polymorphism, Restriction Fragment Length
• Prognosis
• Risk Factors