[Protective effect of a commercial vaccine, poludan and their combinations in an experimental herpes infection].

Abstract

The antiviral action of herpes vaccine and poludan, an interferon-inducing agent, has been studied in experimental herpes infection, and the synergic effect of these preparations has been obtained. The best result (survival rate equal to 100% after the intraperitoneal inoculation of herpes simplex virus and 85.7% after its intracerebral inoculation) has been registered after the multiple vaccination of experimental animals and the injection of poludan 1 day before the challenge of the animals with the virus. The protective effect of the synergic action of the preparations under study coincides with the period of the maximum content of antibodies in the blood sera of the animals.

• Authors: E V Khaletskaia, L L Fadeeva, A Iu Selezneva, T B Semenova
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 2 Pg. 51-4 (Feb 1987) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Izuchenie zashchitnogo éffekta kommercheskoĭ vaktsiny, poludana i ikh kombinatsiĭ pri éksperimental'noĭ gerpeticheskoĭ infektsii.
• PMID: 2437741 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Interferon Inducers
• Polyribonucleotides
• Viral Vaccines
• poludan
• Interferons

Topics

• Animals
• Antibodies, Viral (analysis)
• Drug Evaluation, Preclinical
• Drug Synergism
• Drug Therapy, Combination
• Herpes Simplex (immunology, mortality, prevention & control)
• Interferon Inducers (therapeutic use)
• Interferons (blood)
• Mice
• Polyribonucleotides
• Simplexvirus (immunology)
• Time Factors
• Viral Vaccines (therapeutic use)