Eales' disease is an idiopathic
retinal vasculitis of the eye. The disease is predominantly characterized by recurrent
vitreous hemorrhage.
Interphotoreceptor retinol-binding protein 3 plays a significant role in the etiopathogenesis of this condition. It transports
retinoids between the retinal pigment epithelium and the photoreceptors; hence, this
protein is a potential target for docking studies. In silico data reveal that herbal molecules interact with regulatory domains of
interphotoreceptor retinol-binding protein 3 (IRBP-3), resulting into significant docking score and also forms H-bond and several hydrophobic interactions between active residues of IRBP-3. These interactions between the active residues may lead to significant conformational change in that particular portion of the
protein. This efficacy and suitability of
ligand was determined on the basis of binding energy calculations.
Ginkgolide showed minimum binding energy calculations among selected 10 other natural
ligands. This fact of virtual screening for potential
ligand can give new insights toward the therapeutic intonations and alterations toward the advances in treatment for
Eales' disease.