Decrease in formalin-inactivated respiratory syncytial virus (FI-RSV) enhanced disease with RSV G glycoprotein peptide immunization in BALB/c mice.

Abstract

Respiratory syncytial virus (RSV) is a high priority target for vaccine development. One concern in RSV vaccine development is that a non-live virus vaccine would predispose for enhanced disease similar to that seen with the formalin inactivated RSV (FI-RSV) vaccine. Since a mAb specific to RSV G protein can reduce pulmonary inflammation and eosinophilia seen after RSV infection of FI-RSV vaccinated mice, we hypothesized that RSV G peptides that induce antibodies with similar reactivity may limit enhanced disease after subunit or other non-live RSV vaccines. In support of this hypothesis, we show that FI-RSV vaccinated mice administered RSV G peptide vaccines had a significant reduction in enhanced disease after RSV challenge. These data support the importance of RSV G during infection to RSV disease pathogenesis and suggest that use of appropriately designed G peptide vaccines to reduce the risk of enhanced disease with non-live RSV vaccines merits further study.

• Authors: Gertrud U Rey, Congrong Miao, Hayat Caidi, Suvang U Trivedi, Jennifer L Harcourt, Ralph A Tripp, Larry J Anderson, Lia M Haynes
• Journal: PloS one (PLoS One) Vol. 8 Issue 12 Pg. e83075 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 24376637 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antibodies, Viral
• G glycoprotein, Respiratory syncytial virus
• Peptides
• Respiratory Syncytial Virus Vaccines
• Vaccines, Inactivated
• Viral Fusion Proteins
• Formaldehyde

Topics

• Amino Acid Sequence
• Animals
• Antibodies, Viral (blood)
• Formaldehyde
• Immunization
• Lung (drug effects, immunology, virology)
• Mice
• Mice, Inbred BALB C
• Molecular Sequence Data
• Peptides (administration & dosage, chemistry, immunology)
• Respiratory Syncytial Virus Infections (immunology, prevention & control, virology)
• Respiratory Syncytial Virus Vaccines (administration & dosage, immunology)
• Respiratory Syncytial Viruses (chemistry, immunology)
• Vaccines, Inactivated
• Viral Fusion Proteins (chemistry, immunology)