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Associations between Fas/FasL polymorphisms and susceptibility to cervical cancer: a meta-analysis.

AbstractUNLABELLED:
Genetic polymorphisms in the Fas/Fas ligand (FasL) gene were proposed to be associated with susceptibility to cervical cancer, but previous studies reported controversial findings. We performed a meta-analysis to assess the associations between Fas/FasL polymorphisms and susceptibility to cervical cancer. We carried out a literature search in PubMed and Embase databases for studies on the associations between Fas/FasL polymorphisms and susceptibility to cervical cancer. The associations were assessed by odds ratio (OR) together with its 95% confidence intervals (CIs). Eleven individual studies with a total of 6,919 subjects were finally included into the meta-analysis. Overall, there was no association between Fas 1377G > A polymorphism and susceptibility to cervical cancer (A vs. G: OR = 0.99, 95% CI 0.88-1.12, P = 0.91; AA vs. GG: OR = 1.00, 95% CI 0.76-1.32, P = 0.99; AA/GA vs. GG: OR = 0.95, 95% CI 0.81-1.12, P = 0.54; AA vs.
GG/GA:
OR = 1.11, 95% CI 0.85-1.43, P = 0.45). In addition, there was also no association between FasL 844 T > C polymorphism and susceptibility to cervical cancer (C vs. T: OR = 1.12, 95% CI 0.91-1.36, P = 0.28; CC vs. TT: OR = 1.17, 95% CI 0.90-1.51, P = 0.24; CC/TC vs. TT: OR = 1.13, 95% CI 0.92-1.39, P = 0.24; CC vs.
TT/TC:
OR = 1.11, 95% CI 0.83-1.50, P = 0.47). In subgroup analysis by ethnicity, there were also no associations between Fas/FasL polymorphisms and susceptibility to cervical cancer in Asians and Africans. In conclusion, Fas 1377G > A polymorphism and FasL 844 T > C polymorphism are both not associated with susceptibility to cervical cancer.
AuthorsGuo-qing Wang, Lei Bao, Xi-xia Zhao, Jun Zhang, Ke-jun Nan
JournalTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 5 Pg. 4107-12 (May 2014) ISSN: 1423-0380 [Electronic] Netherlands
PMID24375196 (Publication Type: Journal Article, Meta-Analysis)
Chemical References
  • Antigens, CD95
  • Fas Ligand Protein
Topics
  • Antigens, CD95 (genetics)
  • Fas Ligand Protein (genetics)
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Polymorphism, Genetic
  • Risk
  • Uterine Cervical Neoplasms (etiology, genetics)

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