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Antihyperglycemic and hypolipidemic effects of Hibiscus schizopetalus (Mast) Hook in alloxan-induced diabetic rats.

Abstract
The antihyperglycemic and hypolipidemic activities of Hibiscus schizopetalus (Mast) Hook (Malvaceae) flower and leaves extracts were investigated in alloxan-induced diabetic rats. The hypoglycemic activity of both the extracts (100mg/kg, body weight) was tested in fasting normal rat, glucose loaded rats. Observation on body weight was also recorded. The extracts showed a significant (p<0.001) reduction in blood glucose level in normal fasting rats. In glucose tolerance test, significant (p<0.01) decreased observed in all glucose loaded animals. While in alloxan induced diabetic rats, the percent blood glucose reduction was 59.94% and 45.14% in extracts treated groups. The results obtained were compared with the reference standard drug Tolbutamide (100mg/kg, body weight). The diabetic rats showed sign of decreased in their body weight during the treatment period. Cholesterol and triglycerides levels were significantly decreased (p<0.001) by HFE. The results obtained demonstrated the potential hypoglycemic activity of methanolic extracts of H. schizopetalus. There is need of bioassay-directed assay of the active principles responsible for the anti-diabetic activity. The methanolic extracts showed the presence of carbohydrates, alkaloids, steroids, terpenes, saponins and glycosides.
AuthorsHina Zahid, Ghazala H Rizwani, Huma Shareef, Raheela Khursheed, Ambreen Huma, S M Farid Hasan
JournalPakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 27 Issue 1 Pg. 83-9 (Jan 2014) ISSN: 1011-601X [Print] Pakistan
PMID24374457 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Lipids
  • Plant Extracts
  • Alloxan
  • Tolbutamide
Topics
  • Alloxan
  • Animals
  • Blood Glucose (analysis)
  • Diabetes Mellitus, Experimental (blood, drug therapy)
  • Female
  • Hibiscus
  • Hypoglycemic Agents (therapeutic use)
  • Hypolipidemic Agents (therapeutic use)
  • Lipids (blood)
  • Male
  • Phytotherapy
  • Plant Extracts (therapeutic use)
  • Rats
  • Tolbutamide (therapeutic use)

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