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Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.

Abstract
A series of 17 selected natural and semisynthetic 1,4-naphthoquinones were synthesized, and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six human cancer cell lines using the MTT colorimetric assay. The data revealed that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity, recording mean IC50 values ranging from 15 to 22 μM.
AuthorsSerena Fiorito, Francesco Epifano, Céline Bruyère, Véronique Mathieu, Robert Kiss, Salvatore Genovese
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 24 Issue 2 Pg. 454-7 (Jan 15 2014) ISSN: 1464-3405 [Electronic] England
PMID24374273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Growth Inhibitors
  • Naphthoquinones
  • Plant Extracts
  • lapachol
Topics
  • Antineoplastic Agents, Phytogenic (chemistry, therapeutic use)
  • Cell Line, Tumor
  • Colorimetry (methods)
  • Growth Inhibitors (chemistry, therapeutic use)
  • Humans
  • Naphthoquinones (chemistry, therapeutic use)
  • Neoplasms (drug therapy, pathology)
  • Plant Extracts (chemistry, therapeutic use)

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