Sustained improvement in health-related quality of life measures in patients with inflammatory bowel disease receiving prolonged anti-tumor necrosis factor therapy.

The aim of this study was to determine whether the effects of prolonged therapy (≥1 year) with anti-tumor necrosis factor (TNF) agents were sustained on the health-related quality of life (HRQoL) in patients with inflammatory bowel disease (IBD).
A cross-sectional survey of patients with IBD who were treated with anti-TNF agents was performed. Results of the validated HRQoL measures (inflammatory bowel disease questionnaire [IBDQ], EuroQoL-5 dimensions [EQ-5D], health status visual analogue scale [VAS] and the Zung self-rating depression scale) were recorded and compared between patients treated with anti-TNF agents for <1 year and ≥1 year.
A total of 41 patients were finally enrolled in the study. Among them, 11 (26.8%) had received anti-TNF therapy for less than one year with a median duration of 7 months (range 3-11 months), while the other 30 (73.2%) had been treated for ≥1 year with a median duration of 42 months (range 12-104 months). Crohn's disease was the most common type in both groups. None of the mean IBDQ, EQ-5D and EQ-5D plus VAS, or Zung self-rating depression scale scores differed significantly between the two groups of patients.
Improvements in HRQoL for IBD patients on anti-TNF therapy were sustained for longer than one year. HRQoL measures for IBD patients treated with anti-TNF therapy for <1 year do not differ significantly from those treated for ≥1 year, but a trend towards improved HRQoL measures with prolonged therapy can be obtained.
AuthorsMichael Sherman, Donald N Tsynman, Albert Kim, Jyoti Arora, Timothy Pietras, Susan Messing, Lydia St Hilaire, Sonia Yoon, Arthur Decross, Ashok Shah, Lawrence Saubermann
JournalJournal of digestive diseases (J Dig Dis) Vol. 15 Issue 4 Pg. 174-9 (Apr 2014) ISSN: 1751-2980 [Electronic] Australia
PMID24373601 (Publication Type: Journal Article)
Copyright© 2013 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gastrointestinal Agents
  • Immunosuppressive Agents
  • Tumor Necrosis Factor-alpha
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
  • Cross-Sectional Studies
  • Drug Administration Schedule
  • Drug Evaluation (methods)
  • Female
  • Gastrointestinal Agents (administration & dosage, therapeutic use)
  • Health Status Indicators
  • Humans
  • Immunosuppressive Agents (administration & dosage, therapeutic use)
  • Inflammatory Bowel Diseases (drug therapy, rehabilitation)
  • Male
  • Middle Aged
  • Psychometrics
  • Quality of Life
  • Time Factors
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)
  • Young Adult

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