The effect of trans-4-guanidinomethylcyclohexanecarboxylic acid p-tert-butylphenyl ester hydrochloride (NCO-650) on Ascaris suum antigen-induced bronchoconstriction in dogs.

Abstract

Antiallergic asthma effect of trans-4-guanidinomethylcyclohexane-carboxylic acid p-tert-butylphenyl ester hydrochloride (NCO-650), a new anti-allergic drug, was investigated in comparison with those of tranilast and disodium cromoglycate (DSCG) in anesthetized dogs. The asthmatic bronchoconstriction was induced by inhalation of Ascaris suum antigen (Asc-Ag) to naturally Ascaris-sensitive dogs. The airway resistance was determined using the modified Konzett-Rössler method. Both intravenous (1 and 5 mg/kg) and intraduodenal (10, 30 and 100 mg/kg) administrations of NCO-650 prior to the antigen challenge markedly inhibited the asthmatic bronchoconstriction induced by Asc-Ag inhalation. The antiasthmatic effect of NCO-650 was much stronger than that of DSCG (10 mg/kg, i.v.) and was about three-fold stronger than that of tranilast. On the other hand, when NCO-650 was administered after the antigen challenge, the agent had no inhibitory effect on the Asc-Ag induced bronchoconstriction. As for the effects on increased airway secretion at the time of asthmatic attack, NCO-650 inhibited the excessive secretions without any remarkable change in the viscosity of the secretions. NCO-650 had no effect on the bronchoconstriction induced by inhalation of acetylcholine, suggesting that NCO-650 appears to have no anti-cholinergic effect and thus no effect on the vagal reflex that occurred during the asthmatic responses. The above findings show that NCO-650 may be useful for the treatment of bronchial asthma as an orally active drug.

• Authors: M Misawa, K Takenouchi, M Sato, S Yanaura
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 43 Issue 1 Pg. 53-60 (Jan 1987) ISSN: 0021-5198 [Print] Japan
• PMID: 2437348 (Publication Type: Journal Article)

Chemical References

• Antigens, Helminth
• Cyclohexanecarboxylic Acids
• Protease Inhibitors
• ortho-Aminobenzoates
• NCO 650
• tranilast
• Acetylcholine
• Cromolyn Sodium

Topics

• Acetylcholine (pharmacology)
• Animals
• Antigens, Helminth (immunology)
• Ascaris (immunology)
• Asthma (etiology, prevention & control)
• Bronchi (drug effects)
• Cromolyn Sodium (pharmacology)
• Cyclohexanecarboxylic Acids (pharmacology)
• Dogs
• Hypersensitivity, Immediate
• Male
• Protease Inhibitors (pharmacology)
• Skin Tests
• ortho-Aminobenzoates (pharmacology)