Abstract | BACKGROUND: HYPOTHESIS: Administration of a RD to PNAz dogs treated with benazepril (Be) improves proteinuria control compared with the administration of a maintenance diet (MD). ANIMALS: METHODS: Randomized open label clinical trial design. Dogs were assigned to group-MD (5.5 g protein/100 kcal ME)/Be or to group-RD (3.7 g protein/100 kcal ME)/Be group during 60 days. Dogs with serum albumin ( Alb) <2 g/dL received aspirin (1 mg/kg/12 hours). A physical examination, systolic blood pressure (SBP) measurement, complete blood count (CBC), biochemistry panel, urinalysis, and UPC were performed at day 0 (D0) and day 60 (D60). RESULTS: At D0, there were no significant differences between groups in the evaluated variables. During the study, logUPC (geometric mean (95% CI) and SBP (mean±SD mmHg) significantly decreased (paired t-test, P = 0.001) in Group-RD (logUPC(D0) = 3.16[1.9-5.25]; UPC(D60) = 1.20 [0.59-2.45]; SBP(D0) = 160 ± 17.2; SBP(D60) = 151 ± 15.8), but not in Group-MD (UPC(D0) = 3.63[2.69-4.9]; UPC(D60) = 2.14 [0.76-6.17]; SBP(D0) = 158 ± 14.7; SBP(D60) = 153 ± 11.5). However, RM-ANOVA test did not confirm that changes were consequence of dietary modification. Weight and Alb concentration did not change significantly in any group. CONCLUSION AND CLINICAL RELEVANCE: The administration of a RD to PNAz dogs treated with Be might help to control proteinuria and SBP compared with the administration of a MD, without inducing clinically detectable malnutrition, but more studies are warranted.
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Authors | O Cortadellas, J Talavera, M J Fernández del Palacio |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2014 Jan-Feb
Vol. 28
Issue 1
Pg. 30-7
ISSN: 1939-1676 [Electronic] United States |
PMID | 24372810
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2013 by the American College of Veterinary Internal Medicine. |
Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Benzazepines
- Serum Albumin
- Creatinine
- benazepril
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Animals
- Benzazepines
(therapeutic use)
- Blood Cell Count
(veterinary)
- Blood Chemical Analysis
(veterinary)
- Blood Pressure
- Creatinine
(urine)
- Dog Diseases
(drug therapy, pathology)
- Dogs
- Proteinuria
(diet therapy, veterinary)
- Renal Insufficiency, Chronic
(drug therapy, pathology, veterinary)
- Serum Albumin
(analysis)
- Urinalysis
(veterinary)
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