Raised serum alpha-fetoprotein in Sertoli-Leydig cell tumor (androblastoma) of ovary: report of two cases.

Abstract

Two cases of Sertoli-Leydig cell tumor (SLCT) of the ovary associated with elevated serum alpha-fetoprotein (AFP) levels are described. A 16-year-old girl (case 1) had a Sertoli-Leydig cell tumor containing heterologous elements in the form of mucinous epithelium; AFP was demonstrated within the Sertoli cells by immunohistochemical techniques. An 11-month-old girl (case 2) had a SLCT with a retiform pattern and heterologous elements in the form of cells resembling hepatocytes; AFP was localized in the hepatocytes by immunohistochemical techniques.

• Authors: S Chadha, W J Honnebier, A Schaberg
• Journal: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 6 Issue 1 Pg. 82-8 ( 1987) ISSN: 0277-1691 [Print] United States
• PMID: 2437064 (Publication Type: Case Reports, Journal Article)

Chemical References

• alpha-Fetoproteins

Topics

• Adolescent
• Female
• Humans
• Infant
• Ovarian Neoplasms (blood, pathology)
• Sertoli-Leydig Cell Tumor (blood, pathology)
• alpha-Fetoproteins (analysis)