The purpose of this study was to explore the curative efficacy for nasal type
extranodal NK/T-cell lymphoma by autologous
peripheral blood stem cell transplantation (APBSCT) after sequencing
chemotherapy and
radiotherapy. A total 65 cases diagnosed as nasal type
extranodal NK/T-cell lymphoma by pathology and immuno-histochemistry were treated with
chemotherapy and
radiotherapy in our hospital from January of 2000 to December of 2009. They were divided into observation group (34 cases) and
transplantation group (31 cases). The 34 cases of observation group were ceased from treatment, the 31 cases in
transplantation group received APBSCT after conditioning regimen with TBI combined VEMAC. Autologous peripheral blood stem cells were mobilized with
chemotherapy combined rhG-CSF. The patients were followed up for 3-5 years. The results showed that some side-effects such as bone marrow suppression and injure of oral cavity mucosa were found in patients after sequencing
chemotherapy and
radiotherapy. All patients in
transplantation group obtained hematopoietic reconstruction, and there were no any special side effect such as VOD. In
transplantation group, the median time of ANC ≥ 0.5×10(9)/L was 14 (11-17) days, median time of WBC count ≥ 4.0×10(9)/L was 17 (16-20) days, median time of Plt count ≥ 50×10(8)/L were 25 (23-28) days. After
chemotherapy and
radiotherapy, effective rate of treatment was 91.2% in observation group, whereas was 90.3% in
transplantation group, there were no obvious difference between two groups (P > 0.05). After following up about 1 year, effective rate of treatment was 76.5% in observation group, whereas was 96.8% in
transplantation group, there were obvious difference between two groups (P < 0.05). After following up about 3 years and 5 years the disease-free survival (DFS) was 61.3%, 43.5% and 87.1%, 81.5% in observation group and
transplantation group, there was significant difference between two groups (P < 0.05). It is concluded that treatment with APBSCT after sequencing
chemotherapy and
radiotherapy for nasal type
extranodal NK/T-cell lymphoma may increase DFS efficiently.