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Successful treatment of bulky granulocytic sarcoma of the retroperitoneum with high-dose chemotherapy and autologous peripheral blood stem cell transplantation.

Abstract
Granulocytic sarcoma is a rare disease that is rarely curable with conventional chemotherapy. This report describes a case of a patient with bulky granulocytic sarcoma of the retroperitoneum who was treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation without administering granulocyte colony-stimulating factor before stem cell collection. According to bone marrow assessment and imaging studies, the patient remained in complete remission at 5 years after transplantation. This case suggests that high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation is a therapeutic option for granulocytic sarcoma.
AuthorsTakahiro Matsui, Michihiro Hidaka, Tetsuyuki Kiyokawa, Toshihiko Murayama, Fumio Kawano
JournalJournal of clinical and experimental hematopathology : JCEH (J Clin Exp Hematop) Vol. 53 Issue 3 Pg. 235-9 ( 2013) ISSN: 1880-9952 [Electronic] Japan
PMID24369226 (Publication Type: Case Reports, Journal Article)
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bone Marrow (pathology)
  • Humans
  • Male
  • Peripheral Blood Stem Cell Transplantation
  • Retroperitoneal Neoplasms (diagnosis, therapy)
  • Sarcoma, Myeloid (diagnosis, therapy)
  • Tomography, X-Ray Computed
  • Transplantation Conditioning
  • Transplantation, Autologous
  • Treatment Outcome

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