HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Vagotomy/drainage is superior to local oversew in patients who require emergency surgery for bleeding peptic ulcers.

AbstractOBJECTIVE:
To compare early postoperative outcomes of patients undergoing different types of emergency procedures for bleeding or perforated gastroduodenal ulcers.
BACKGROUND:
Although definitive acid-reducing procedures are being used less frequently during emergency ulcer surgery, there is little published data to support this change in practice.
METHODS:
A retrospective analysis of data for patients from the 2005-2011 American College of Surgeons National Surgical Quality Improvement Program database who underwent emergency operation for bleeding or perforated peptic ulcer disease was performed to determine the association between surgical approach (local procedure alone, vagotomy/drainage, or vagotomy/gastric resection) and 30-day postoperative outcomes. Multivariable regression analysis was used to adjust for a number of patient-related factors.
RESULTS:
A total of 3611 patients undergoing emergency ulcer surgery (775 for bleeding, 2374 for perforation) were included for data analysis. Compared with patients undergoing local procedures alone, vagotomy/gastric resection was associated with significantly greater postoperative morbidity when performed for either ulcer perforation or bleeding. For patients with perforated ulcers, vagotomy/drainage produced similar outcomes as local procedures but required a significantly greater length of postoperative hospitalization. Conversely, vagotomy/drainage was associated with a significantly lower postoperative mortality rate than local ulcer oversew when performed for bleeding ulcers.
CONCLUSIONS:
Simple repair is the procedure of choice for patients requiring emergency surgery for perforated peptic ulcer disease. For patients requiring emergency operation for intractable ulcer bleeding, vagotomy/drainage is associated with lower postoperative mortality than with simple ulcer oversew.
AuthorsVanessa T Schroder, Theodore N Pappas, Steven N Vaslef, Sebastian G De La Fuente, John E Scarborough
JournalAnnals of surgery (Ann Surg) Vol. 259 Issue 6 Pg. 1111-8 (Jun 2014) ISSN: 1528-1140 [Electronic] United States
PMID24368635 (Publication Type: Journal Article)
Topics
  • Aged
  • Drainage (methods)
  • Duodenal Ulcer (mortality, surgery)
  • Emergencies
  • Female
  • Follow-Up Studies
  • Gastrectomy (methods)
  • Hospital Mortality (trends)
  • Humans
  • Length of Stay (trends)
  • Male
  • Middle Aged
  • Peptic Ulcer Hemorrhage (mortality, surgery)
  • Peptic Ulcer Perforation (mortality, surgery)
  • Postoperative Period
  • Retrospective Studies
  • Stomach Ulcer (mortality, surgery)
  • Survival Rate (trends)
  • Treatment Outcome
  • United States (epidemiology)
  • Vagotomy (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: