Predictors of acute and persisting ischemic brain lesions in patients randomized to carotid stenting or endarterectomy.

Abstract

BACKGROUND AND PURPOSE:

We investigated predictors for acute and persisting periprocedural ischemic brain lesions among patients with symptomatic carotid stenosis randomized to stenting or endarterectomy in the International Carotid Stenting Study.

METHODS:

We assessed acute lesions on diffusion-weighted imaging 1 to 3 days after treatment in 124 stenting and 107 endarterectomy patients and lesions persisting on fluid-attenuated inversion recovery after 1 month in 86 and 75 patients, respectively.

RESULTS:

Stenting patients had more acute (relative risk, 8.8; 95% confidence interval, 4.4-17.5; P<0.001) and persisting lesions (relative risk, 4.2; 95% confidence interval, 1.6-11.1; P=0.005) than endarterectomy patients. Acute lesion count was associated with age (by trend), male sex, and stroke as the qualifying event in stenting; high systolic blood pressure in endarterectomy; and white matter disease in both groups. The rate of conversion from acute to persisting lesions was lower in the stenting group (relative risk, 0.4; 95% confidence interval, 0.2-0.8; P=0.007), and was only predicted by acute lesion volume.

CONCLUSIONS:

Stenting caused more acute and persisting ischemic brain lesions than endarterectomy. However, the rate of conversion from acute to persisting lesions was lower in the stenting group, most likely attributable to lower acute lesion volumes. Clinical Trial Registration -URL: www.isrctn.org. Unique identifier: ISRCTN25337470.

• Authors: Ayda Rostamzadeh, Thomas Zumbrunn, Lisa M Jongen, Paul J Nederkoorn, Sumaira Macdonald, Philippe A Lyrer, L Jaap Kappelle, Willem P Th M Mali, Martin M Brown, H Bart van der Worp, Stefan T Engelter, Leo H Bonati, ICSS-MRI Substudy Investigators
• Journal: Stroke (Stroke) Vol. 45 Issue 2 Pg. 591-4 (Feb 2014) ISSN: 1524-4628 [Electronic] United States
• PMID: 24368558 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Topics

• Acute Disease
• Brain Ischemia (epidemiology)
• Carotid Arteries (surgery)
• Carotid Stenosis (surgery)
• Confidence Intervals
• Diffusion Magnetic Resonance Imaging
• Endarterectomy, Carotid (statistics & numerical data)
• Female
• Follow-Up Studies
• Humans
• Hypertension (complications)
• Image Processing, Computer-Assisted
• Male
• Predictive Value of Tests
• Regression Analysis
• Risk Assessment
• Risk Factors
• Sex Characteristics
• Stents (statistics & numerical data)