Kruppel-like factor 6 in the progression and prognosis of malignant melanoma.

Abstract

OBJECTIVES:

The aims of this study were to investigate the incidence of Krüppel-like factor 6 (KLF6) protein staining in patients with cutaneous malignant melanoma and examine its potential relevance to clinicopathological characteristics and tumour cell proliferation.

METHODS:

Clinicopathological data from patients with cutaneous malignant melanoma were analysed retrospectively. Presence of KLF6 and the antigen Ki-67 in malignant melanoma and healthy tissue samples from each patient was detected by immunohistochemistry. The proliferation index was calculated on the basis of Ki-67 expression. The relationship between KLF6 and clinicopathological characteristics was also analysed.

RESULTS:

KLF6 was detected more frequently in normal healthy skin tissue compared with cutaneous malignant melanoma lesions (n = 40). There was a negative correlation between the presence of KLF6 and the proliferation index. The presence of KLF6 was also significantly correlated with tumour diameter, lymph node metastasis, tumour-node-metastasis stage and 3-year survival rate.

CONCLUSIONS:

KLF6 protein is downregulated in human cutaneous malignant melanoma lesions compared with healthy skin tissue. KLF6 may be involved in tumour progression and may be a tumour suppressor and prognostic marker for cutaneous malignant melanoma.

• Authors: Daxing Cai, Jing Zhao, Qing Sun
• Journal: The Journal of international medical research (J Int Med Res) Vol. 42 Issue 1 Pg. 184-90 (Feb 2014) ISSN: 1473-2300 [Electronic] England
• PMID: 24366496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• KLF6 protein, human
• Ki-67 Antigen
• Kruppel-Like Factor 6
• Kruppel-Like Transcription Factors
• Proto-Oncogene Proteins

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Disease Progression
• Female
• Humans
• Ki-67 Antigen (metabolism)
• Kruppel-Like Factor 6
• Kruppel-Like Transcription Factors (metabolism, physiology)
• Male
• Melanoma (metabolism, pathology)
• Middle Aged
• Prognosis
• Proto-Oncogene Proteins (metabolism, physiology)
• Skin Neoplasms (metabolism, pathology)