Abstract | INTRODUCTION: There are limited data on the efficacy of early fluid resuscitation with third-generation hydroxyethyl starch (HES 130) in burn injury. Adverse effects of HES on survival and organ function have been reported. METHODS: RESULTS: Three-day totals of administered resuscitation fluid (medians) were 21,190 mL in the lactated Ringer's group and 19,535 mL in the HES group (HES: -1,213 mL; P = 0.39). Creatinine levels from day 1 to 3 (HES: +0.4 μmol/L; 95% confidence interval (CI) -18.7 to 19.5; P = 0.97) and urinary outputs from day 1 to 3 (HES: -58 mL; 95% CI -400 to 283; P = 0.90) were not different. Six patients in each group developed acute respiratory distress syndrome (ARDS) (risk ratio 0.96; 95% CI 0.35 to 2.64; P = 0.95). Length of ICU stay (HES vs. lactated Ringer's: 28 vs. 24 days; P = 0.80) and length of hospital stay (31 vs. 29 days; P = 0.57) were similar. Twenty-eight-day mortality was 4 patients in each group (risk ratio 0.96; 95% CI 0.27 to 4.45; P = 0.95), and in-hospital mortality was 8 in the HES group vs. 5 patients in the lactated Ringer's group (hazard ratio 1.86; 95% CI 0.56 to 6.19; P = 0.31). CONCLUSIONS: TRIAL REGISTRATION: ClinicalTrials.gov NCT01012648.
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Authors | Markus Béchir, Milo A Puhan, Mario Fasshauer, Reto A Schuepbach, Reto Stocker, Thomas A Neff |
Journal | Critical care (London, England)
(Crit Care)
Vol. 17
Issue 6
Pg. R299
(Dec 23 2013)
ISSN: 1466-609X [Electronic] England |
PMID | 24365167
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- HES 130-0.4
- Hydroxyethyl Starch Derivatives
- Isotonic Solutions
- Ringer's Lactate
- Creatinine
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Topics |
- Burns
(complications, mortality, therapy)
- Creatinine
(urine)
- Double-Blind Method
- Drug Administration Schedule
- Female
- Fluid Therapy
- Hospital Mortality
- Humans
- Hydroxyethyl Starch Derivatives
(therapeutic use)
- Intensive Care Units
- Isotonic Solutions
(therapeutic use)
- Length of Stay
- Male
- Middle Aged
- Prospective Studies
- Respiratory Distress Syndrome
(etiology)
- Ringer's Lactate
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