A rare but severe complication of filgrastim in a healthy donor: splenic rupture.

Abstract

BACKGROUND:

Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture.

CASE STUDY:

In this case, we report a 40 year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6 cm.

RESULTS:

She was followed conservatively. One month later the CT scan signs of rupture disappeared.

CONCLUSION:

We must pay attention to this rare but serious adverse event during filgrastim use.

• Authors: Gulsah Akyol, Cigdem Pala, Afra Yildirim, Muzaffer Keklika, Koray Demir, Sumeyra Dortdudak, Serdar Sivgin, Leylagul Kaynar, Bulent Esera, Ali Unal, Mustafa Cetin
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 50 Issue 1 Pg. 53-5 (Feb 2014) ISSN: 1473-0502 [Print] England
• PMID: 24360843 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor
• Filgrastim

Topics

• Abdominal Pain
• Adult
• Blood Donors
• Female
• Filgrastim
• Granulocyte Colony-Stimulating Factor (adverse effects, therapeutic use)
• Hematopoietic Stem Cell Mobilization (adverse effects)
• Hematopoietic Stem Cell Transplantation
• Humans
• Recombinant Proteins (adverse effects)
• Splenic Rupture (etiology)
• Tomography, X-Ray Computed