[Effects of gender on treatment strategies for elderly patients with acute coronary syndrome].

To explore the effects of gender on treatment strategies for elderly patients with acute coronary syndrome (ACS).
March 2009 to March 2012, consecutive 619 aged ACS patients undergoing coronary angiography (CA) were screened at our hospital. There were 273 females and 346 males. Risk factors, ACS diagnosis, CA results, treatments and prognosis were compared between female and male groups.
The risk factors of body mass index, stroke history, smoking history, hemoglobin (Hb), serum cholesterol (TC), low density lipoprotein (LDL-C) and blood uric acid (UA) levels were significantly lower in female group than those in male group (P < 0.05). The morbidity of diabetes in female group was obviously higher than that in male group (27.8% vs 18.5%, P < 0.05). The prevalence of myocardial infarction history, percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) history in male group were significantly greater than that in female group (48.0% vs 39.9%, P < 0.05; 30.6% vs 22.3%, P < 0.05; 19.9% vs 10.3%, P < 0.01). The rate of combined multiple risk factors (3 or higher) increased significantly in female group (41.8% vs 29.8%, P < 0.05). The incidence of unstable angina pectoris (UAP) and non-ST segment elevation myocardial infarction (NSTEMI) in female group was greater, but there was no statistical significance. The rate of 3-vessel and calcification lesions in female group was significantly elevated compared with male group (36.26% vs 28.61%, P < 0.05). Regarding the choice of treatment strategy, conservative treatment was common in females, but there was no statistical significance between them. PCI, emergency PCI and selective CABG operation were performed more frequently in female group compared with male group (26.0% vs 14.2%, P < 0.01; 14.7% vs 6.6%, P < 0.01; 19.1% vs 7.7%, P < 0.01). The prognosis had no statistical significance between two groups.
The treatment strategies have certain limitations for female ACS patients. And an more aggressive treatment should be offered to improve the prognosis.
AuthorsMei-ping Cui, Bin Zhang, Wen-bin Jiang, Ming-zhen Zhu, Xian-yan Jiang, Ling-hua Zhu, Yu Chang, Xiao Guo, Song-tao Wang, Chang-hong Lu, Yi-ping Ge, Feng-xia Qu
JournalZhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 93 Issue 34 Pg. 2739-41 (Sep 10 2013) ISSN: 0376-2491 [Print] China
PMID24360111 (Publication Type: English Abstract, Journal Article)
  • Acute Coronary Syndrome (therapy)
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Prognosis
  • Risk Factors
  • Sex Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: