[Efficacy and safety of ambrisentan therapy in Chinese patients with pulmonary hypertension].

Abstract

OBJECTIVE:

To explore the efficacy, safety and tolerance of ambrisentan, a high-selective endothelin receptor antagonist, in Chinese patients with pulmonary hypertension (PH).

METHODS:

Twenty-eight PH patients (Group 1+Group 4) came from Shanghai East Hospital, Zhongshan Hospital of Fudan University and Fifth People's Hospital of Shanghai were recruited into this open-label, prospective multi-center trial between August 2012 and February 2013. They received 2.5-5.0 mg ambrisentan once daily for 12 weeks. The primary endpoint was the change in exercise capacity showed by six-minute walk distance (6MWD) from baseline to 12 weeks. Secondary endpoints included the changes in World Health Organization (WHO) function class, N-terminal brain natriuretic peptide (NT-proBNP) and liver function test results.

RESULTS:

There were 9 males and 19 females with an average age of (35 ± 17) years. The value of 6MWD increased from (372 ± 86) m at baseline to (443 ± 96) m (P = 0.000) after 12 weeks. WHO functional class improved after a 12-week therapy compared to the baseline level (P = 0.000). NT-proBNP decreased from a median of 732 ng/L at baseline to 329 ng/L after 12 weeks (P = 0.046). The baseline liver function test was normal. And liver function test didn't significantly change after a 12-week therapy.

CONCLUSION:

Ambrisentan therapy is well-tolerated and it improves the exercise capacity and WHO function class in Chinese PH patients.

• Authors: Fa-dong Chen, Da-xin Zhou, Ruo-min Di, Yu Zou, Wei Wei, Xue-bo Liu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 93 Issue 34 Pg. 2736-8 (Sep 10 2013) ISSN: 0376-2491 [Print] China
• PMID: 24360110 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Antihypertensive Agents
• Phenylpropionates
• Pyridazines
• ambrisentan

Topics

• Adolescent
• Adult
• Antihypertensive Agents (adverse effects, therapeutic use)
• Female
• Humans
• Hypertension, Pulmonary (drug therapy)
• Male
• Middle Aged
• Phenylpropionates (adverse effects, therapeutic use)
• Prospective Studies
• Pyridazines (adverse effects, therapeutic use)
• Treatment Outcome
• Young Adult