Methotrexate as a treatment in ocular cicatricial moderate pemphigoid.

Abstract

CLINICAL CASE:

A 73 year-old woman presented with a history of non-specific symptoms and photophobia in both eyes of 1 year progression. The examination revealed a bilateral symblepharon and fornix shortening. Immunohistochemical analysis confirmed the presence of linear deposits of IgG, IgM and C3 along the conjunctival basement membrane. With the diagnosis of Ocular Cicatricial Pemphigoid, systemic treatment with subcutaneous methotrexate was prescribed.

DISCUSSION:

We consider such treatment a very effective initial immunosuppressive alternative in patients with moderate conjunctival inflammation and in cases of rapid progression.

• Authors: A Hervás Ontiveros, D Salom, E España Gregori, E Jiménez Herrero, M Díaz-Llopis
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 89 Issue 11 Pg. 447-9 (Nov 2014) ISSN: 1989-7286 [Electronic] Spain
• PMID: 24359845 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.

Chemical References

• Complement C3
• Immunoglobulin G
• Immunoglobulin M
• Immunosuppressive Agents
• Methotrexate

Topics

• Aged
• Basement Membrane (immunology)
• Complement C3 (analysis)
• Conjunctiva (pathology)
• Female
• Humans
• Hyperemia (etiology)
• Immunoglobulin G (analysis)
• Immunoglobulin M (analysis)
• Immunosuppressive Agents (therapeutic use)
• Keratitis (etiology)
• Methotrexate (therapeutic use)
• Pemphigoid, Benign Mucous Membrane (complications, diagnosis, drug therapy, immunology)