HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Generalized verrucosis in a patient with GATA2 deficiency.

Abstract
Generalized verrucosis is a characteristic of several genetic and immunodeficiency disorders including epidermodysplasia verruciformis; warts, hypogammaglobulinaemia, infections and myelokathexis (WHIM) syndrome; warts, immunodeficiency, lymphoedema and anogenital dysplasia (WILD) syndrome; severe combined immune deficiency and HIV, among others. In recent years, it has been consistently recognized in patients with GATA2 deficiency, a novel immunodeficiency syndrome characterized by monocytopenia, B-cell and natural killer-cell lymphopenia, and a tendency to develop myeloid leukaemias and disseminated mycobacterial, human papillomavirus (HPV) and opportunistic fungal infections. Mutations in GATA2 cause haploinsufficiency and track in families as an autosomal dominant immunodeficiency. GATA2 is a transcription factor involved in early haematopoietic differentiation and lymphatic and vascular development. We describe a case of generalized verrucosis with HPV type 57 presenting in a young man with GATA2 deficiency. GATA2 deficiency is a novel dominant immunodeficiency that is often recognized later in life and should be considered in the differential diagnosis of patients with generalized verrucosis.
AuthorsE S West, M Y Kingsbery, E M Mintz, A P Hsu, S M Holland, P L Rady, S K Tyring, M E Grossman
JournalThe British journal of dermatology (Br J Dermatol) Vol. 170 Issue 5 Pg. 1182-6 (May 2014) ISSN: 1365-2133 [Electronic] England
PMID24359037 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Intramural)
Copyright© 2013 British Association of Dermatologists.
Chemical References
  • GATA2 Transcription Factor
Topics
  • GATA2 Transcription Factor (deficiency, genetics)
  • Humans
  • Immunologic Deficiency Syndromes (genetics)
  • Male
  • Mutation (genetics)
  • Pedigree
  • Skin Neoplasms (genetics)
  • Warts (genetics)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: