Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells.

Abstract

Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. In addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies.

• Authors: João Agostinho Machado-Neto, Paula de Melo Campos, Patricia Favaro, Mariana Lazarini, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Teresinha Olalla Saad, Fabiola Traina
• Journal: Leukemia research (Leuk Res) Vol. 38 Issue 2 Pg. 251-7 (Feb 2014) ISSN: 1873-5835 [Electronic] England
• PMID: 24355524 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• STMN1 protein, human
• Stathmin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Cell Proliferation
• Female
• Humans
• Leukemia, Myeloid, Acute (genetics, pathology)
• Male
• Middle Aged
• Myelodysplastic Syndromes (genetics, pathology)
• Neoplasm Invasiveness
• Phenotype
• Risk
• Stathmin (genetics, physiology)
• Tumor Cells, Cultured
• U937 Cells
• Young Adult