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Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma.

Abstract
Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr-old male patient. Remarkably, treatment with a high-dose cytarabine regimen led to rapid remineralization of all bone lesions and recovery of the patient's mobility within a few weeks. Thereby, surgical treatment and radiotherapy could be avoided, supporting the role of intensive induction and standard consolidation chemotherapy as first-line treatment for myeloid sarcoma.
AuthorsSebastian Brähler, Indra Thielen, Hendrik Schwabe, Marianne Engels, Karl-Anton Kreuzer, Jürgen Wolf, Sascha Ansén
JournalEuropean journal of haematology (Eur J Haematol) Vol. 92 Issue 6 Pg. 537-40 (Jun 2014) ISSN: 1600-0609 [Electronic] England
PMID24354760 (Publication Type: Case Reports, Journal Article)
Copyright© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Chemical References
  • Antimetabolites, Antineoplastic
  • Cytarabine
Topics
  • Antimetabolites, Antineoplastic (administration & dosage, adverse effects)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Biopsy
  • Bone Diseases (diagnosis, etiology)
  • Bone Marrow (pathology)
  • Calcinosis (diagnosis, etiology)
  • Cytarabine (administration & dosage, adverse effects)
  • Humans
  • Immunophenotyping
  • Male
  • Middle Aged
  • Sarcoma, Myeloid (complications, diagnosis, drug therapy)
  • Tomography, X-Ray Computed
  • Treatment Outcome

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