Abstract |
Isolated myeloid sarcoma is a rare presentation of acute myeloid leukemia. There are limited data available concerning the prognostic relevance and the right treatment strategy for this clinical scenario. Here, we report a case of acute myeloid leukemia with extensive lesions and fractures in multiple bones in a 64-yr-old male patient. Remarkably, treatment with a high-dose cytarabine regimen led to rapid remineralization of all bone lesions and recovery of the patient's mobility within a few weeks. Thereby, surgical treatment and radiotherapy could be avoided, supporting the role of intensive induction and standard consolidation chemotherapy as first-line treatment for myeloid sarcoma.
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Authors | Sebastian Brähler, Indra Thielen, Hendrik Schwabe, Marianne Engels, Karl-Anton Kreuzer, Jürgen Wolf, Sascha Ansén |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 92
Issue 6
Pg. 537-40
(Jun 2014)
ISSN: 1600-0609 [Electronic] England |
PMID | 24354760
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antimetabolites, Antineoplastic
- Cytarabine
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Topics |
- Antimetabolites, Antineoplastic
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biopsy
- Bone Diseases
(diagnosis, etiology)
- Bone Marrow
(pathology)
- Calcinosis
(diagnosis, etiology)
- Cytarabine
(administration & dosage, adverse effects)
- Humans
- Immunophenotyping
- Male
- Middle Aged
- Sarcoma, Myeloid
(complications, diagnosis, drug therapy)
- Tomography, X-Ray Computed
- Treatment Outcome
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