Abstract | BACKGROUND: OBJECTIVES: SEARCH METHODS: We searched the Cochrane Schizophrenia Group Trials Register (15 November 2012) and inspected references of all identified studies for further relevant studies. We were to contact the first author of each included study for information regarding unpublished trials. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: We inspected the results of the search to identify relevant studies. We were to extract data onto standard, simple forms. Disagreements were resolved through discussion. The risk of bias was to be assessed using the Cochrane risk assessment tool. For binary outcomes, we were to calculate a standard estimation of the risk ratio (RR) and its 95% confidence interval (CI). For continuous outcomes, we were to estimate the mean difference between groups. MAIN RESULTS: AUTHORS' CONCLUSIONS: We have been unable to locate any studies addressing the question raised in this review. Accordingly, this empty review points out an important clinical problem that needs to be investigated via well-designed and well-conducted randomised trials. Clinicians and patients are likely to continue with their current dependence on clinical judgement and personal experience. Policy makers have no trial-based evidence upon which to base guidelines for the treatment of hypersalivation induced by neuroleptics other than clozapine. They are likely to continue to rely on opinion and habit when making recommendations. Funders of studies may wish to make this important subgroup of people a priority in future research.
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Authors | Adib Essali, Anas Rihawi, Mohammad Altujjar, Bishr Alhafez, Amjad Tarboush, Nahla Alhaj Hasan |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 12
Pg. CD009546
(Dec 19 2013)
ISSN: 1469-493X [Electronic] England |
PMID | 24353163
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Antipsychotic Agents
- Cholinergic Antagonists
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Topics |
- Antipsychotic Agents
(adverse effects)
- Cholinergic Antagonists
(therapeutic use)
- Humans
- Schizophrenia
(drug therapy)
- Sialorrhea
(chemically induced, drug therapy)
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