Metal-N-heterocyclic carbene complexes as anti-tumor agents.

Abstract

It has been a long story of the development of anticancer metallopharmaceuticals since the identification of cisplatin. Advances in metallodrugs discovery during the past 40 years have made it an ever-growing area of research in medicinal inorganic chemistry. Meanwhile, the emerging of N-heterocyclic carbene (NHC) chemistry has stimulated the newly burgeoning interests in the biomedical applications of metal-NHC complexes. This review will detail what have been achieved hitherto in the research of metal-NHC complexes as potential anti-tumor agents coupled with gold, silver, copper, platinum and palladium. Their mechanism of action will also be discussed. All the results obtained indicate that this promising approach is worthy of more focuses and further studies.

• Authors: Chunqi Hu, Xin Li, Wei Wang, Ruoyu Zhang, Liping Deng
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 21 Issue 10 Pg. 1220-30 (Apr 2014) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 24350852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Coordination Complexes
• Heterocyclic Compounds
• carbene
• Auranofin
• Silver
• Platinum
• Palladium
• Gold
• Copper
• Methane
• Cisplatin

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Auranofin (chemistry, pharmacology)
• Cell Line, Tumor
• Cisplatin (chemistry, pharmacology)
• Coordination Complexes (chemical synthesis, pharmacology)
• Copper (chemistry)
• Gold (chemistry)
• Heterocyclic Compounds (chemical synthesis, pharmacology)
• Humans
• Methane (analogs & derivatives, chemistry)
• Neoplasms (drug therapy)
• Palladium (chemistry)
• Platinum (chemistry)
• Silver (chemistry)
• Structure-Activity Relationship