Abstract | AIMS AND OBJECTIVES: MATERIALS AND METHODS: Patients were randomly allocated to the two treatment groups and advised to apply either agent topically twice-a-day for 4 weeks on the lesions and fluconazole (150 mg) was administered once a week for 4 weeks in the study group applying Whitfield's ointment. Patients were followed-up at an interval of 10 days for clinical score and global evaluation response was assessed at baseline and during each follow-up. RESULTS: Out of 120 patients enrolled in the study 103 completed the study. Patients treated with Whitfield's ointment and oral fluconazole reduced mean sign and symptom score from 8.81 ± 0.82 to 0.18 ± 0.59 while butenafine treated patients reduced it from 8.88 ± 0.53 to 0.31 ± 0.67 at the end of the treatment. Nearly, 98% patients were completely cleared of the lesion on the 3(rd) follow-up with both treatments. CONCLUSION:
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Authors | Saket J Thaker, Dimple S Mehta, Hiral A Shah, Jayendra N Dave, Kunjan M Kikani |
Journal | Indian journal of pharmacology
(Indian J Pharmacol)
2013 Nov-Dec
Vol. 45
Issue 6
Pg. 622-4
ISSN: 1998-3751 [Electronic] India |
PMID | 24347774
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antifungal Agents
- Benzoates
- Benzylamines
- Drug Combinations
- Naphthalenes
- Salicylates
- Whitfield's Ointment
- Fluconazole
- butenafine
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Topics |
- Administration, Oral
- Administration, Topical
- Antifungal Agents
(administration & dosage, therapeutic use)
- Benzoates
(therapeutic use)
- Benzylamines
(administration & dosage, therapeutic use)
- Cost-Benefit Analysis
- Drug Combinations
- Drug Therapy, Combination
- Fluconazole
(administration & dosage, therapeutic use)
- Humans
- Naphthalenes
(administration & dosage, therapeutic use)
- Prospective Studies
- Salicylates
(therapeutic use)
- Skin Diseases
(drug therapy)
- Tinea
(drug therapy)
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