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A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin.

AbstractAIMS AND OBJECTIVES:
The aim of this study is to compare the efficacy, safety and cost-effectiveness of topical Whitfield's ointment plus oral fluconazole with topical 1% butenafine in tinea infections of the skin.
MATERIALS AND METHODS:
Patients were randomly allocated to the two treatment groups and advised to apply either agent topically twice-a-day for 4 weeks on the lesions and fluconazole (150 mg) was administered once a week for 4 weeks in the study group applying Whitfield's ointment. Patients were followed-up at an interval of 10 days for clinical score and global evaluation response was assessed at baseline and during each follow-up.
RESULTS:
Out of 120 patients enrolled in the study 103 completed the study. Patients treated with Whitfield's ointment and oral fluconazole reduced mean sign and symptom score from 8.81 ± 0.82 to 0.18 ± 0.59 while butenafine treated patients reduced it from 8.88 ± 0.53 to 0.31 ± 0.67 at the end of the treatment. Nearly, 98% patients were completely cleared of the lesion on the 3(rd) follow-up with both treatments.
CONCLUSION:
Whitfield's ointment with oral fluconazole is as efficacious, safe and cost-effective as compared with 1% butenafine in tinea infections of the skin.
AuthorsSaket J Thaker, Dimple S Mehta, Hiral A Shah, Jayendra N Dave, Kunjan M Kikani
JournalIndian journal of pharmacology (Indian J Pharmacol) 2013 Nov-Dec Vol. 45 Issue 6 Pg. 622-4 ISSN: 1998-3751 [Electronic] India
PMID24347774 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antifungal Agents
  • Benzoates
  • Benzylamines
  • Drug Combinations
  • Naphthalenes
  • Salicylates
  • Whitfield's Ointment
  • Fluconazole
  • butenafine
Topics
  • Administration, Oral
  • Administration, Topical
  • Antifungal Agents (administration & dosage, therapeutic use)
  • Benzoates (therapeutic use)
  • Benzylamines (administration & dosage, therapeutic use)
  • Cost-Benefit Analysis
  • Drug Combinations
  • Drug Therapy, Combination
  • Fluconazole (administration & dosage, therapeutic use)
  • Humans
  • Naphthalenes (administration & dosage, therapeutic use)
  • Prospective Studies
  • Salicylates (therapeutic use)
  • Skin Diseases (drug therapy)
  • Tinea (drug therapy)

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