Abstract |
The purpose of the present study was to evaluate the possible therapeutic effects and the safety of Mangifera indica extract ( Vimang tablets, 300 mg) combined with methotrexate (MTX) on reducing disease activity in rheumatoid arthritis (RA). Twenty patients with active RA underwent a year of treatment with MTX (12.5 mg/week) associated to non-steroidal anti-inflammatory drugs ( NSAIDs) and/or prednisone (5-10 mg/day) were randomly allocated to the experimental group (n=10), that received the extract supplementation (900 mg/day) or preceding usual treatment (n=10) during 180 days. RA activity was evaluated using the tender and swollen joint counts, erythrocyte sedimentation rate, disease activity score-28 ( DAS 28), visual analogue scale (VAS) and health assessment questionnaire ( HAQ). Treatment's efficacy was demonstrated with ACR criteria. Only the patients of MTX- Vimang group revealed statistically significant improvement in DAS 28 parameters with respect baseline data but no differences were observed between groups. ACR improvements amounted 80% only in MTX- Vimang group at the 90 days (p<0.001). In MTX- Vimang group, 100% of patients decreased NSAIDs administration (p<0.01) and 70% of those eradicated gastrointestinal side effects (p<0.01) ensuing of the preceding treatment. Other adverse effects were not reported.
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Authors | Ana M López Mantecón, Gabino Garrido, René Delgado-Hernández, Bárbara B Garrido-Suárez |
Journal | Phytotherapy research : PTR
(Phytother Res)
Vol. 28
Issue 8
Pg. 1163-72
(Aug 2014)
ISSN: 1099-1573 [Electronic] England |
PMID | 24344049
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 John Wiley & Sons, Ltd. |
Chemical References |
- Antirheumatic Agents
- Mangifera indica extract
- Plant Extracts
- Methotrexate
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Topics |
- Adult
- Aged
- Antirheumatic Agents
(therapeutic use)
- Arthritis, Rheumatoid
(drug therapy)
- Drug Therapy, Combination
- Female
- Humans
- Male
- Mangifera
(chemistry)
- Methotrexate
(therapeutic use)
- Middle Aged
- Pilot Projects
- Plant Extracts
(therapeutic use)
- Treatment Outcome
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