Lamotrigine use in patients with binge eating and purging, significant affect dysregulation, and poor impulse control.

Abstract

OBJECTIVE:

Some patients with symptoms of binge eating and purging are successfully treated with specific serotonin reuptake inhibitors (SSRIs), but others experience only partial or no benefit. Significant affect dysregulation and poor impulse control may be characteristics that limit responsiveness.

METHOD:

We report on the treatment of five patients with bulimia nervosa (BN), anorexia nervosa-binge/purge type (AN-B/P) or eating disorder not otherwise specified (EDNOS), using the anticonvulsant lamotrigine after inadequate response to SSRIs.

RESULTS:

Following addition of lamotrigine to an antidepressant in four cases, and switch from an antidepressant to lamotrigine in one case, patients experienced substantial improvement in mood reactivity and instability, impulsive drives and behaviors, and eating-disordered symptoms.

DISCUSSION:

These findings raise the possibility that lamotrigine, either as monotherapy or as an augmenting agent to antidepressants, may be useful in patients who binge eat and purge, and have significant affect dysregulation with poor impulse control.

• Authors: Mary Ellen Trunko, Terry A Schwartz, Enrica Marzola, Angela S Klein, Walter H Kaye
• Journal: The International journal of eating disorders (Int J Eat Disord) Vol. 47 Issue 3 Pg. 329-34 (Apr 2014) ISSN: 1098-108X [Electronic] United States
• PMID: 24343841 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Wiley Periodicals, Inc.

Chemical References

• Anticonvulsants
• Serotonin Uptake Inhibitors
• Triazines
• Lamotrigine

Topics

• Adolescent
• Affect (drug effects)
• Anorexia Nervosa (drug therapy)
• Anticonvulsants (therapeutic use)
• Binge-Eating Disorder (drug therapy)
• Body Mass Index
• Bulimia Nervosa (drug therapy)
• Disruptive, Impulse Control, and Conduct Disorders (drug therapy, prevention & control)
• Drug Therapy, Combination
• Female
• Humans
• Lamotrigine
• Selective Serotonin Reuptake Inhibitors (therapeutic use)
• Treatment Outcome
• Triazines (therapeutic use)
• Young Adult