[Scintigraphic detection of malignancies with radioactively labelled tumor antibodies. Clinical results based on immunohistochemical research].

Abstract	69 patients with different tumors (colorectal, melanoma, testicle, ovary, bladder, carcinoid, lungs) were investigated by radioimmunoscintigraphy. The corresponding antibodies or their F(ab')2 fragments against CEA (n = 30), melanoma antigen (n = 25), TPA (n = 6), beta-HCG (n = 5), HMFG-2 (n = 2) and CEA/CA 19-9 (n = 1) were selected on the basis of immunohistochemical investigations of the primary tumors. The precision was 62%, and the number of false-negative findings was 32%. Additional clinical information (detection or exclusion of a suspected recurrence) could be obtained in 22 patients. From these results, it can be concluded that the corresponding tumor antibodies should be selected on the basis of immunohistochemical investigations of the primary tumor before performing radioimmunoscintigraphy to screen for recurrences or metastases.
Authors	H J Biersack, A Bockisch, J Vogel, P Oehr, H H Hansen, J Hartlapp, H Biltz, N Jaeger, O Bellmann
Journal	Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 112 Issue 9 Pg. 341-4 (Feb 27 1987) ISSN: 0012-0472 [Print] Germany
Vernacular Title	Szintigraphischer Malignomnachweis mit radioaktiv markierten Tumorantikörpern. Klinische Ergebnisse auf der Basis immunhistochemischer Untersuchungen.
PMID	2434296 (Publication Type: Journal Article)
Chemical References	Antibodies, Monoclonal Antibodies, Neoplasm Antigens, Neoplasm Antigens, Surface Antigens, Tumor-Associated, Carbohydrate Carcinoembryonic Antigen Chorionic Gonadotropin Chorionic Gonadotropin, beta Subunit, Human Melanoma-Specific Antigens Membrane Proteins Mucin-1 Neoplasm Proteins Peptide Fragments Peptides Tissue Polypeptide Antigen
Topics	Antibodies, Monoclonal Antibodies, Neoplasm (analysis) Antigens, Neoplasm (analysis) Antigens, Surface (analysis) Antigens, Tumor-Associated, Carbohydrate Carcinoembryonic Antigen (analysis) Chorionic Gonadotropin (immunology) Chorionic Gonadotropin, beta Subunit, Human Female Histocytochemistry Humans Male Melanoma (immunology) Melanoma-Specific Antigens Membrane Proteins (analysis) Mucin-1 Neoplasm Proteins (analysis) Neoplasms (diagnostic imaging, immunology, metabolism) Peptide Fragments (immunology) Peptides (analysis) Radionuclide Imaging Tissue Polypeptide Antigen

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