Abstract | BACKGROUND & AIMS: METHODS: We performed a retrospective analysis of data from 1014 patients with liver biopsy-confirmed nonalcoholic fatty liver disease. Three cut points of serum ferritin level, adjusted for sex, were established based on receiver operating characteristic curve analysis: 1.0-, 1.5-, and 2.0-fold the upper limit of normal. Three multiple logistic regression models were created to determine the association of these cutoff values with liver fibrosis, adjusting for age, sex, race, diabetes, body mass index, and level of alanine aminotransferase. RESULTS: A greater proportion of patients with increased serum levels of ferritin had definitive nonalcoholic steatohepatitis and more-advanced fibrosis than patients without increased levels. In all models, serum level of ferritin was significantly associated with the presence and severity of liver fibrosis. However, for all 3 cutoff values, area under the receiver operating characteristic curve values were low (less than 0.60) for the presence of fibrosis or any stage of liver fibrosis; ferritin level identified patients with fibrosis with 16%-41% sensitivity and 70%-92% specificity. The accuracy with which noninvasive scoring systems identified patients with advanced fibrosis did not change with inclusion of serum ferritin values. CONCLUSIONS:
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Authors | Paul Angulo, Jacob George, Christopher P Day, Ester Vanni, Lee Russell, Anna C De la Cruz, Hammad Liaquat, Lavinia Mezzabotta, Eun Lee, Elisabetta Bugianesi |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 12
Issue 7
Pg. 1163-1169.e1
(Jul 2014)
ISSN: 1542-7714 [Electronic] United States |
PMID | 24342745
(Publication Type: Evaluation Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Biomarkers
(blood)
- Biostatistics
- Cohort Studies
- Female
- Ferritins
(blood)
- Humans
- Liver Cirrhosis
(diagnosis)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(complications)
- Retrospective Studies
- Serum
(chemistry)
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