Abstract | INTRODUCTION:
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a pathologic condition of increasing frequency, with a poorly understood pathophysiology and which can be difficult to manage. The aim of this study was to find a reproducible experimental model that directly relates chronic bisphosphonate administration with the development of osteonecrosis with or without tooth extraction, with no other drug involved. MATERIAL AND METHODS: Twenty male Wistar rats were divided into 4 groups (n = 5/group). Animals were injected over 9 weeks with zoledronic acid (0.1 mg/kg). In groups 1 and 2 three times a week intraperitoneally, and in group 3 once a week intravenously. A control group (group 4) received intraperitoneal injections of saline solution three times a week. After 8 weeks of treatment, 3 right upper jaw molars were extracted in groups 1, 3 and 4 and all rats were sacrificed 1 week later. The maxillae were histologically analyzed for presence of osteonecrosis foci, number of osteoclasts, vascularity, bone resorption status and presence of abscess. Radiographic examination was performed with a plain radiograph of each hemi-head. RESULTS: CONCLUSIONS: We offer a new animal model of BRONJ after zoledronic acid administration and dental extractions, achieving bone changes similar or superior to previous studies, highlighting the dental extraction as an important trigger factor.
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Authors | Paula Barba-Recreo, Jose Luis Del Castillo Pardo de Vera, Mariano García-Arranz, Laura Yébenes, Miguel Burgueño |
Journal | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
(J Craniomaxillofac Surg)
Vol. 42
Issue 6
Pg. 744-50
(Sep 2014)
ISSN: 1878-4119 [Electronic] Scotland |
PMID | 24342733
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Zoledronic Acid
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Topics |
- Abscess
(etiology, pathology)
- Alveolar Process
(blood supply, pathology)
- Animals
- Bisphosphonate-Associated Osteonecrosis of the Jaw
(etiology, pathology)
- Bone Density
(drug effects)
- Bone Density Conservation Agents
(administration & dosage, adverse effects)
- Bone Resorption
(etiology, pathology)
- Diphosphonates
(administration & dosage, adverse effects)
- Disease Models, Animal
- Imidazoles
(administration & dosage, adverse effects)
- Injections, Intraperitoneal
- Injections, Intravenous
- Male
- Maxilla
(blood supply, pathology, surgery)
- Molar
(surgery)
- Osteoclasts
(pathology)
- Osteosclerosis
(etiology, pathology)
- Random Allocation
- Rats
- Rats, Wistar
- Tooth Extraction
(adverse effects)
- Zoledronic Acid
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