[Clinical study of iron protein succinylate oral solution for preventing and treating anemia of prematurity].

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of iron protein succinylate (IPS) oral solution in preventing and treating anemia of prematurity (AOP).

METHODS:

Sixty premature infants less than 35 weeks of gestation were randomly divided into IPS (n=30) and polysaccharide iron complex (PIC) groups(n=30). Treatment began at two weeks after birth. The infants received IPS or PIC in addition to recombinant human erythropoietin. On days 14, 28, 42, and 60 after treatment, hemoglobin (Hb), red blood cell count(RBC), hematocrit (HCT), percentage of reticulocytes, serum iron, and serum ferritin were determined. Liver and renal functions were evaluated before and after treatment.

RESULTS:

There were significant differences in the changing trends of RBC and HCT between the two groups (P<0.05). In the IPS group, RBC and HCT gradually decreased after birth, but began to rise gradually on days 28 and 42 of treatment; in the PIC group, RBC and HCT kept decreasing from birth to day 60 of treatment. On day 60 of treatment, the IPS group had significantly higher levels of Hb, RBC, HCT, serum iron, and serum ferritin than the PIC group (P<0.05). No notable adverse events occurred in either group.

CONCLUSIONS:

IPS oral solution has good efficacy and tolerability in preventing and treating AOP.

• Authors: Yan Xing, Xiao-Mei Tong
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 15 Issue 12 Pg. 1059-63 (Dec 2013) ISSN: 1008-8830 [Print] China
• PMID: 24342196 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Hematinics
• Metalloproteins
• Solutions
• Succinates
• Iron
• iron protein succinylate

Topics

• Administration, Oral
• Anemia, Neonatal (blood, drug therapy, prevention & control)
• Erythrocyte Count
• Female
• Hematinics (therapeutic use)
• Hematocrit
• Humans
• Infant, Premature
• Iron (metabolism)
• Male
• Metalloproteins (adverse effects, therapeutic use)
• Solutions
• Succinates (adverse effects, therapeutic use)