Abstract |
Alcohol-related disorders are multifaceted since ethanol can induce profound metabolic perturbations when taken in excess. Global metabolic profiling strategies may aid the understanding of ethanol-related effects by shedding light on these metabolic changes and potentially revealing unknown mechanisms of ethanol toxicity. Here an overview of studies designed to explore the effects of alcohol ( ethanol) consumption using holistic metabolite profiling approaches (metabonomics/metabolomics) is presented, demonstrating the potential of this methodology. The analytical technologies used (NMR, GC-MS and LC-MS), have been applied to the profiling of serum, plasma, urine and tissues, obtained from animal models or humans, after exposure to alcohol. From the metabolic profiling data of a range of biological samples, a number of endogenous metabolites have been proposed as potential ethanol consumption-related biomarkers. The biomarkers suggested by these studies, and the biochemical insights that they provide for understanding the effects of ethanol mechanisms of toxicity, are discussed.
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Authors | Helen G Gika, Ian D Wilson |
Journal | Bioanalysis
(Bioanalysis)
Vol. 6
Issue 1
Pg. 59-77
(Jan 2014)
ISSN: 1757-6199 [Electronic] England |
PMID | 24341495
(Publication Type: Journal Article, Review)
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Chemical References |
- Biomarkers
- Eicosanoic Acids
- Glucuronates
- Indoles
- Sulfuric Acid Esters
- ethyl glucuronide
- eicosa-11,14-dienoic acid
- Ethanol
- indole-3-lactic acid
- diethyl sulfate
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Topics |
- Alcohol-Related Disorders
(blood, diagnosis, urine)
- Animals
- Biomarkers
(blood, urine)
- Chromatography, High Pressure Liquid
- Eicosanoic Acids
(metabolism)
- Ethanol
(administration & dosage, metabolism)
- Glucuronates
(blood, urine)
- Humans
- Indoles
(metabolism)
- Liver
(drug effects, metabolism)
- Magnetic Resonance Spectroscopy
- Metabolome
- Mice
- Rats
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Sulfuric Acid Esters
(blood, urine)
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