Co2/Erbium:YAG/Dye laser combination: an effective and successful treatment for angiofibromas in tuberous sclerosis.

Tuberous sclerosis, an autosomal dominant neurocutaneous syndrome seen in approximately 1 in 6,000 people worldwide, is characterized by the appearance of hamartomas in multiple organs. The classic clinical triad consists of angiofibromas, epilepsy, and developmental delay. Dermatologic disorder is one of the main characteristics. Angiofibromas, a common form of presentation, causes significant cosmetic and medical problems. The current treatment for skin lesions is laser therapy. The carbon dioxide (CO2) laser has been used satisfactorily in treating these lesions, but several studies have demonstrated a high percentage of recurrences. Erbium:yttrium-aluminum-garnet (YAG) laser treatment has been used to resurface skin abnormalities in patients with dermatologic conditions. The dye laser as an alternative uses the principles of selective photothermolysis and is very effective in treating the vascular component of tuberous sclerosis. The use of all these lasers to treat skin lesions in patients affected by tuberous sclerosis has never been described in the literature.
A retrospective study, conducted from 2007 to May 2013, investigated 13 patients who had tuberous sclerosis treated with an erbium:YAG/CO2/dye laser combination.
All the patients showed great improvement of their skin lesions. The results were evident immediately after the first treatment. No patient experienced complications or recurrence.
The combined use of the erbium:YAG/Dye/CO2 laser is a safe and effective treatment for skin lesions in patients affected by tuberous sclerosis.
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AuthorsPaolo Fioramonti, Liliana De Santo, Martina Ruggieri, Sara Carella, Lo Torto Federico, Maria Giuseppina Onesti, Nicolò Scuderi
JournalAesthetic plastic surgery (Aesthetic Plast Surg) Vol. 38 Issue 1 Pg. 192-8 (Feb 2014) ISSN: 1432-5241 [Electronic] United States
PMID24337149 (Publication Type: Journal Article)
Chemical References
  • Carbon Dioxide
  • Adolescent
  • Adult
  • Angiofibroma (surgery)
  • Carbon Dioxide
  • Female
  • Humans
  • Lasers, Dye (therapeutic use)
  • Lasers, Solid-State (therapeutic use)
  • Male
  • Remission Induction
  • Retrospective Studies
  • Skin Neoplasms (surgery)
  • Tuberous Sclerosis (complications)
  • Young Adult

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