A nonadjuvanted transcutaneous tetanus patch is effective in boosting anti-tetanus toxoid immune responses.

Abstract

Dry tetanus toxoid (TTx) patches were formulated without any adjuvant, with excipients to impart antigen stabilization and to enhance skin delivery. The booster effects of the TTx patches were assessed using a guinea pig model. The study revealed significant rises in TTx IgG titers induced by the TTx patches after a low-dose subcutaneous (s.c.) prime with TTx adsorbed to aluminum hydroxide. The TTx patch can therefore be considered an effective alternative to a subcutaneous booster.

• Authors: Robert C Seid Jr, Christoph Reinisch, Robert Schlegl, Michael Moehlen, Andreas Meinke, Urban Lundberg
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 21 Issue 2 Pg. 253-5 (Feb 2014) ISSN: 1556-679X [Electronic] United States
• PMID: 24334688 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial
• Antitoxins
• Immunoglobulin G
• Tetanus Toxoid

Topics

• Administration, Cutaneous
• Animals
• Antibodies, Bacterial (blood)
• Antitoxins (blood)
• Female
• Guinea Pigs
• Immunization, Secondary (methods)
• Immunoglobulin G (blood)
• Tetanus (prevention & control)
• Tetanus Toxoid (administration & dosage, immunology)