[The impact of thyroid function in women of reproductive age: infertility, pregnancy and the postpartum period].

Abstract

This article reviews the management and diagnosis of thyroid dysfunction during pregnancy and postpartum, which was published by any of the endocrine societies in 2012. The author presents human data based on these clinical practice guidelines, however, there are also many unresolved questions. Especially, there are inconsistencies about screening using plasma TSH measurement. In pregnancy the main causes of hyperthyroidism are Graves's disease and gestational transient thyrotoxicosis. Generally, gestational transient thyrotoxicosis does not require medication, whereas Graves's disease needs antithyroid drug therapy. Postpartum thyroiditis occurs more frequently in antithyroid peroxidase-positive women, who should be screened using serum thyrotropin measurements at 6 to 12 gestation weeks and at 3 and 6 months postpartum. Because overt maternal hypothyroidism, due to autoimmune pathophysioloical mechanisms, negatively affects the fetus, timely recognition and treatment are important. The subclinical form of maternal hypothyroidism should also be treated. A link between thyroid dysfunction and infertility has been warranted.

• Authors: Gábor Speer
• Journal: Orvosi hetilap (Orv Hetil) Vol. 154 Issue 51 Pg. 2017-23 (Dec 22 2013) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: A pajzsmirigyműködés jelentősége fertilis korú nőkben: meddőség, terhesség és a post partum időszak.
• PMID: 24334133 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Autoantibodies
• Thyrotropin

Topics

• Adult
• Autoantibodies (blood)
• Diagnosis, Differential
• Female
• Graves Disease (diagnosis)
• Humans
• Hyperthyroidism (blood, complications, diagnosis, etiology)
• Hypothyroidism (blood, complications, diagnosis, immunology)
• Infertility, Female (etiology)
• Mass Screening
• Postpartum Period (blood)
• Practice Guidelines as Topic
• Pregnancy
• Pregnancy Complications (blood, diagnosis)
• Thyroid Function Tests
• Thyroid Gland (immunology, metabolism)
• Thyrotoxicosis (diagnosis)
• Thyrotropin (blood)