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Unilateral optic disk edema with central retinal artery and vein occlusions as the presenting signs of relapse in acute lymphoblastic leukemia.

AbstractCLINICAL CASE:
A 39-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia (LAL Ph+) developed progressive vision loss to no light perception in his right eye. He had optic disk edema and later developed central artery and vein occlusions. Pan-photocoagulation, as well as radiotherapy of the whole brain were performed in several fractions. Unfortunately the patient died of hematological relapse 4 months later.
DISCUSSION:
Optic nerve infiltration may appear as an isolated sign of a leukemia relapse, even before a hematological relapse occurs. Leukemic optic neuropathy is a critical sign, not only for vision, but also for life, and radiotherapy should be immediately performed before irreversible optic nerve damage occurs.
AuthorsR Salazar Méndez, M Fonollá Gil
JournalArchivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 89 Issue 11 Pg. 454-8 (Nov 2014) ISSN: 1989-7286 [Electronic] Spain
PMID24332689 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2013 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Combined Modality Therapy
  • Cord Blood Stem Cell Transplantation
  • Cranial Irradiation
  • Fatal Outcome
  • Humans
  • Leukemic Infiltration (complications, diagnosis, radiotherapy)
  • Light Coagulation
  • Male
  • Papilledema (etiology, radiotherapy)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, pathology, therapy)
  • Recurrence
  • Retinal Artery Occlusion (etiology)
  • Retinal Vein (pathology)

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