New titanocene derivatives with high antiproliferative activity against breast cancer cells.

Abstract

The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests.

• Authors: Carmela Saturnino, Esther Sirignano, Antonio Botta, Maria Stefania Sinicropi, Anna Caruso, Assunta Pisano, Rosamaria Lappano, Marcello Maggiolini, Pasquale Longo
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 24 Issue 1 Pg. 136-40 (Jan 01 2014) ISSN: 1464-3405 [Electronic] England
• PMID: 24332626 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Organometallic Compounds
• titanocene

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Breast Neoplasms (drug therapy, pathology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Female
• Humans
• MCF-7 Cells
• Molecular Structure
• Organometallic Compounds (chemical synthesis, chemistry, pharmacology)
• Stereoisomerism
• Structure-Activity Relationship