Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.

Abstract

BACKGROUND:

Our group has previously shown that EPHRIN-A1 and SCINDERIN expression by tumor cells rendered them resistant to cytotoxic T lymphocyte-mediated lysis. Whereas the prognostic value of EPHRIN-A1 expression in cancer has already been studied, the role of SCINDERIN presence remains to be established. In the present work, we investigated the prognosis value of EPHRIN-A1 and SCINDERIN expression in head and neck carcinomas. In addition, we monitored the HLA-class I expression by tumor cells and the presence of tumor-infiltrating CD8+ T cells to evaluate a putative correlation between these factors and the survival prognosis by themselves or related to EPHRIN-A1 and SCINDERIN expression.

METHODS:

Tumor tissue sections of 83 patients with head and neck cancer were assessed by immunohistochemistry for the expression of EPHRIN-A1, SCINDERIN, HLA class I molecules and the presence of CD8+ T cells.

RESULTS:

No significant prognosis value could be attributed to these factors independently, despite a tendency of association between EPHRIN-A1 and a worse clinical outcome. No prognostic value could be observed when CD8+ T cell tumor infiltration was analyzed combined with EPHRIN-A1, SCINDERIN or HLA class I expression.

CONCLUSION:

These results highlight that molecules involved in cancer cell resistance to cytotoxic T lymphocytes by themselves are not a sufficient criteria for prognosis determination in cancer patients. Other intrinsic or tumor microenvironmental features should be considered in prognostic evaluation.

• Authors: Meriem Hasmim, Cécile Badoual, Philippe Vielh, Françoise Drusch, Virginie Marty, Agnès Laplanche, Mariana de Oliveira Diniz, Hélène Roussel, Eléonore De Guillebon, Stéphane Oudard, Stéphane Hans, Eric Tartour, Salem Chouaib
• Journal: BMC cancer (BMC Cancer) Vol. 13 Pg. 592 (Dec 11 2013) ISSN: 1471-2407 [Electronic] England
• PMID: 24330498 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Ephrin-A1
• Gelsolin
• Histocompatibility Antigens Class I
• scinderin

Topics

• Aged
• Biomarkers, Tumor (metabolism)
• CD8-Positive T-Lymphocytes (immunology)
• Carcinoma, Squamous Cell (immunology, metabolism, mortality, therapy)
• Combined Modality Therapy
• Cytotoxicity, Immunologic
• Ephrin-A1 (metabolism)
• Female
• Gelsolin (metabolism)
• Head and Neck Neoplasms (immunology, metabolism, mortality, therapy)
• Histocompatibility Antigens Class I (metabolism)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Prognosis