An experimental study on choroidal neovascularization induced by Krypton laser in rat model.

The purpose of this work was to study the efficacy and safety of choroidal neovascularization (CNV) formation induced by Krypton laser in Brown Norway (BN) rats, and observe the trend of the change of CNV after laser photocoagulation.
Twenty-five male BN rats were involved in this study. Two eyes of one rat without any laser photocoagulation were randomly selected as the control group, and the other 48 eyes of 24 rats were selected as the experimental group. Eight eyes of four rats were randomly selected to receive the examinations of fundus fluorescein angiography (FFA), histopathology, and transmission electron microscopy 3, 7, 14, 21, 28, and 56 days after laser photocoagulation.
After laser photocoagulation, the leakage appeared in burns on day 7 (59%), reached the peak on day 21 (84%), (p<0.01), and remained stable after day 21, proven by FFA and histopathology (p>0.05). The thickness of CNV increased from day 7 to day 21 (p<0.01), and remained stable after day 21 (p>0.05).
The experimental model of CNV can be successfully induced by Krypton laser in rats with a stable, long-lasting, and high success rate. After laser photocoagulation, the leakages appear on day 7, reach the peak on day 21, and remain stable after day 21.
AuthorsJing Cui, Yuanyuan Liu, Jingkai Zhang, Hua Yan
JournalPhotomedicine and laser surgery (Photomed Laser Surg) Vol. 32 Issue 1 Pg. 30-6 (Jan 2014) ISSN: 1557-8550 [Electronic] United States
PMID24328846 (Publication Type: Journal Article)
  • Animals
  • Choroidal Neovascularization (pathology)
  • Disease Models, Animal
  • Fluorescein Angiography
  • Lasers, Excimer (adverse effects)
  • Male
  • Microscopy, Electron, Transmission
  • Rats

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