Superselective intracerebral catheterization for administration of oncolytic virotherapy in a case of diffuse intrinsic pontine glioma.

Abstract

New therapies are needed to improve current results in diffuse intrinsic pontine glioma. We present here the initial experience of administering Celyvir, autologous mesenchymal stem cells infected with ICOVIR-5, an oncolytic adenovirus that selectively replicates in cancer cells, by means of superselective intra-arterial delivery, in a patient diagnosed of diffuse intrinsic pontine glioma. Feasibility, safety, and morbidity rates of the superselective catheterization technique are comparable with those of diagnostic angiography. The intra-arterial approach warrants a greater contact of the mesenchymal stem cells with the tumor mass, and minimizes hemorrhages or vascular disruption. The tolerance to the 2 administrations was excellent, with no acute or delayed adverse effect, underscoring the feasibility of this technique for the delivery of virotherapies and/or cellular therapies in this location.

• Authors: Fernando Carceller, Aitziber Aleu, Alfredo Casasco, Leopoldo Guimaraens, Migel A López-Pino, Luís Madero, Manuel Ramírez
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 36 Issue 7 Pg. e430-2 (Oct 2014) ISSN: 1536-3678 [Electronic] United States
• PMID: 24327128 (Publication Type: Case Reports, Journal Article)

Topics

• Brain Stem Neoplasms (pathology, therapy)
• Catheterization (methods)
• Child
• Fatal Outcome
• Female
• Glioma (pathology, therapy)
• Humans
• Infusions, Intra-Arterial (methods)
• Mesenchymal Stem Cell Transplantation (methods)
• Oncolytic Virotherapy (methods)