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Safety and efficacy of bimatoprost solution 0.03% topical application in patients with chemotherapy-induced eyelash loss.

Abstract
Few dermatologic conditions carry as much anxiety and emotional distress as hair loss resulting from a disease condition such as alopecia areata or as a result of cytotoxic drug treatment, e.g., after chemotherapy. Bimatoprost 0.03% solution is a Food and Drug Administration-approved prescription product indicated for the treatment of eyelash hypotrichosis. The product was investigated in a double-masked, randomized, and placebo-controlled study in patients who had significant eyelash loss or hypotrichosis as a result of chemotherapy. Once-daily treatment with bimatoprost ophthalmic solution 0.03% to the upper eyelid margin restored eyelash growth and prominence more quickly than the slower, natural course of recovery observed in the vehicle control subjects. The eyelash prominence measured using a validated Global Eyelash Assessment (GEA) scale demonstrated a statistically significant increase over placebo following 6 months of treatment. Efficacy was also demonstrated using a validated objective digital image analysis methodology to show significant increase in eyelash length, thickness/fullness, and darkness in these patients. Bimatoprost was found to be well tolerated over the 1-year treatment period.
AuthorsGurpreet S Ahluwalia
JournalThe journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research (J Investig Dermatol Symp Proc) Vol. 16 Issue 1 Pg. S73-6 (Dec 2013) ISSN: 1529-1774 [Electronic] United States
PMID24326568 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Amides
  • Antineoplastic Agents
  • Dermatologic Agents
  • Cloprostenol
  • Bimatoprost
Topics
  • Amides (adverse effects, therapeutic use)
  • Antineoplastic Agents (adverse effects)
  • Bimatoprost
  • Cloprostenol (adverse effects, analogs & derivatives, therapeutic use)
  • Dermatologic Agents (adverse effects, therapeutic use)
  • Double-Blind Method
  • Eyelashes
  • Humans
  • Hypotrichosis (chemically induced, drug therapy)
  • Patient Satisfaction
  • Severity of Illness Index

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