Abstract | BACKGROUND AND AIM: METHODS: We described the cumulative serologic, virologic, and biochemical outcomes and the occurrence of signature entecavir mutations among 222 Chinese treatment-naïve chronic hepatitis B (CHB) patients receiving entecavir for up to 5 years. RESULTS: The median rate of HBsAg reduction over 5 years was 0.125 log IU/mL/year. Patients with high baseline HBV DNA levels (≥ 8 log copies/mL or ≥ 7.3 log IU/mL), when compared with those with baseline hepatitis B virus (HBV) DNA < 7.3 log IU/mL, had a significantly greater median rate of HBsAg reduction (0.178 and 0.102 log IU/mL/year, respectively, P < 0.001). The difference in HBsAg decline was most prominent in the first year (0.324 and 0.062 log IU/mL/year, respectively, P < 0.001). Greater median rates of HBsAg reduction were also found in hepatitis B e antigen ( HBeAg)-positive patients when compared with HBeAg-negative patients (0.144 and 0.098 log IU/mL/year, P = 0.015), and in patients with high baseline HBsAg levels (≥ 3 log IU/mL), when compared with patients with low baseline HBsAg < 3 log IU/mL (0.131 and 0.045 log IU/mL/year, respectively, P = 0.001). The 5-year cumulative rate of HBV DNA undetectability (< 20 IU/mL) was 97.1%. There were two cases of entecavir resistance, resulting in a 5-year cumulative resistance rate of 1.2%. CONCLUSION: In contrast to the profound HBV DNA suppression, long-term entecavir treatment achieved only a slow decline in serum HBsAg. Although certain patient subgroups exhibit a more rapid HBsAg reduction, additional therapeutic agents are needed to increase the chance of HBsAg seroclearance in CHB.
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Authors | Wai-Kay Seto, Yuk-Fai Lam, James Fung, Danny Ka-Ho Wong, Fung-Yu Huang, Ivan Fan-Ngai Hung, Ching-Lung Lai, Man-Fung Yuen |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 29
Issue 5
Pg. 1028-34
(May 2014)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 24325451
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Antiviral Agents
- Biomarkers
- DNA, Viral
- Hepatitis B Surface Antigens
- entecavir
- Guanine
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Topics |
- Adult
- Aged
- Antiviral Agents
(therapeutic use)
- Asian People
- Biomarkers
(blood)
- DNA, Viral
(blood)
- Female
- Guanine
(analogs & derivatives, therapeutic use)
- Hepatitis B Surface Antigens
(blood)
- Hepatitis B virus
(drug effects, genetics, immunology)
- Hepatitis B, Chronic
(drug therapy, virology)
- Humans
- Male
- Middle Aged
- Pregnancy
- Time Factors
- Young Adult
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