Abstract | PURPOSE: METHODS: Eight patients with persistent and/or worsening CRC symptoms, despite conventional therapy, received biweekly intravesical instillation of PDRNs for two consecutive months. Symptoms were scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT- SOMA) scale, before, at the end, and after 4 months following the PDRNs treatment. RESULTS: Four months after instillations, a significant improvement in the subjective perception of CRC symptoms was experienced by participants. The mean LENT- SOMA score was reduced from 1.16+0.26 before to 0.34+0.035 after 4 months from instillations (p<0.001). No adverse effect related to instillations was reported. CONCLUSIONS: Subjective perception of persistent and/or worsening CRC symptoms, despite conventional therapy, is improved after intravesical instillation with PDRNs without adverse events. Even though we deduced suggestive insights, the results need to be collected and verified from a large-scale study.
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Authors | Pierluigi Bonfili, Pietro Franzese, Francesco Marampon, Maria Emilia La Verghetta, Silvia Parente, Manuela Cerasani, Daniela Di Genova, Marta Mancini, Francesca Vittorini, Giovanni Luca Gravina, Valeria Ruggieri, Mario Di Staso, Vladimir M Popov, Vincenzo Tombolini, Ernesto Di Cesare |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 22
Issue 5
Pg. 1155-9
(May 2014)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 24322388
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Intravesical
- Aged
- Cystitis
(drug therapy, etiology)
- Female
- Humans
- Male
- Middle Aged
- Pelvic Neoplasms
(radiotherapy)
- Pelvis
(radiation effects)
- Pilot Projects
- Polydeoxyribonucleotides
(administration & dosage)
- Radiation Injuries
(drug therapy, etiology)
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