Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties.

Abstract

Two new sesquiterpene lactones, namely feruhodin A and feruhodin B, together with six known compounds, daucoeudesmanolactone, dehydrooopodin, oopodin, badkhysin, 7-demethylplastochromenol, and scoparone, were isolated from the roots of Ferula oopoda. The structures of these compounds were elucidated by 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Cytotoxic effects of these compounds were evaluated against two human cancer cell lines including MCF7and K562 using the Alamar blue assay. The results showed that dehydrooopodin possessed significant cytotoxic effects with IC₅₀ values of 15 and 5 μM against MCF7 and K562, respectively.

• Authors: Jamal Kasaian, Milad Iranshahy, Milena Masullo, Sonia Piacente, Fatemeh Ebrahimi, Mehrdad Iranshahi
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 16 Issue 3 Pg. 248-53 ( 2014) ISSN: 1477-2213 [Electronic] England
• PMID: 24320993 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Coumarins
• Lactones
• Sesquiterpenes
• feruhodin A
• feruhodin B
• scoparone

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Coumarins (isolation & purification)
• Drug Screening Assays, Antitumor
• Female
• Ferula (chemistry)
• Humans
• Iran
• K562 Cells
• Lactones (chemistry, isolation & purification, pharmacology)
• MCF-7 Cells
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Plant Roots (chemistry)
• Sesquiterpenes (chemistry, isolation & purification, pharmacology)