HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Topical treatment of experimental skin lesions in rats: macroscopic, microscopic and scanning electron-microscopic evaluation of the healing process.

Abstract
The effects of the topical antiseptic agents mercurochrome and silver nitrate and of sodium hyaluronate on the process of wound healing were assessed by macroscopic examination, light microscopy histology, electron microscopy and scanning electron microscopy of wounds made by cutting or by abrasion of the skin of rats. It was found that wounds treated with hyaluronic acid underwent longer periods of inflammation (proportional to the presence of mastocytes) and greater amounts of collagen deposition than wounds that were either untreated controls or treated with silver nitrate or mercurochrome, but this did not impede the formation in the early stages of healing of bridges of fibrin between the edges of the wounds.
AuthorsE Trabucchi, F Preis Baruffaldi, C Baratti, W Montorsi
JournalInternational journal of tissue reactions (Int J Tissue React) Vol. 8 Issue 6 Pg. 533-44 ( 1986) ISSN: 0250-0868 [Print] Switzerland
PMID2432029 (Publication Type: Journal Article)
Chemical References
  • Anti-Infective Agents, Local
  • Hyaluronic Acid
  • Silver Nitrate
  • Merbromin
Topics
  • Administration, Topical
  • Animals
  • Anti-Infective Agents, Local (therapeutic use)
  • Hyaluronic Acid (therapeutic use)
  • Male
  • Merbromin (therapeutic use)
  • Microscopy, Electron, Scanning
  • Rats
  • Rats, Inbred Strains
  • Silver Nitrate (therapeutic use)
  • Skin (injuries, ultrastructure)
  • Wound Healing (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: