HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Modification of collagen formation by mesenchymal stem cells isolated from human adipose tissue in culture and after autotransplantation for abdominal hernia plasty.

Abstract
Mesenchymal stem cells from the adipose tissue of patients with postoperative hernias produce excessive amounts of collagen III, which shifts the balance between type III and type I collagens. The proposed technique of pretransplantation preparation allows in vitro stimulation collagen formation processes with predominant activation of collagen I synthesis and normalization of proportion between different collagen types. Abdominal wall repair with polypropylene surgical mesh in combination with autotransplantation of mesenchymal stem cells reduced the collagen III to collagen I ratio due to activation of collagen I synthesis and suppression of collagen III production, which had a positive effect on the structure of in vivo formed connective tissue.
AuthorsV G Bogdan, M M Zafranskaya, Yu M Gain, Yu E Demidchik, S S Bagatka, G I Ivanchik
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 156 Issue 1 Pg. 152-5 (Nov 2013) ISSN: 1573-8221 [Electronic] United States
PMID24319714 (Publication Type: Journal Article)
Chemical References
  • Collagen Type I
  • Collagen Type III
Topics
  • Adipose Tissue, White (pathology)
  • Autografts
  • Cells, Cultured
  • Collagen Type I (metabolism)
  • Collagen Type III (metabolism)
  • Combined Modality Therapy
  • Hernia, Abdominal (metabolism, therapy)
  • Herniorrhaphy
  • Humans
  • Mesenchymal Stem Cell Transplantation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: