Abstract |
Mesenchymal stem cells from the adipose tissue of patients with postoperative hernias produce excessive amounts of collagen III, which shifts the balance between type III and type I collagens. The proposed technique of pretransplantation preparation allows in vitro stimulation collagen formation processes with predominant activation of collagen I synthesis and normalization of proportion between different collagen types. Abdominal wall repair with polypropylene surgical mesh in combination with autotransplantation of mesenchymal stem cells reduced the collagen III to collagen I ratio due to activation of collagen I synthesis and suppression of collagen III production, which had a positive effect on the structure of in vivo formed connective tissue.
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Authors | V G Bogdan, M M Zafranskaya, Yu M Gain, Yu E Demidchik, S S Bagatka, G I Ivanchik |
Journal | Bulletin of experimental biology and medicine
(Bull Exp Biol Med)
Vol. 156
Issue 1
Pg. 152-5
(Nov 2013)
ISSN: 1573-8221 [Electronic] United States |
PMID | 24319714
(Publication Type: Journal Article)
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Chemical References |
- Collagen Type I
- Collagen Type III
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Topics |
- Adipose Tissue, White
(pathology)
- Autografts
- Cells, Cultured
- Collagen Type I
(metabolism)
- Collagen Type III
(metabolism)
- Combined Modality Therapy
- Hernia, Abdominal
(metabolism, therapy)
- Herniorrhaphy
- Humans
- Mesenchymal Stem Cell Transplantation
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