Is anti-D immunoglobulin still a frontline treatment option for immune thrombocytopenia?

Abstract

A 5-year-old boy presents with platelet count of 2×10(9)/L and clinical and laboratory evidence of immune thrombocytopenia. He has epistaxis and oral mucosal bleeding. Complete blood count reveals isolated thrombocytopenia without any decline in hemoglobin and he is Rh+. You are asked if anti-D immunoglobulin is an appropriate initial therapy for this child given the 2010 Food and Drug Administration "black-box" warning.

• Authors: Jenny M Despotovic, Cindy E Neunert
• Journal: Hematology. American Society of Hematology. Education Program (Hematology Am Soc Hematol Educ Program) Vol. 2013 Pg. 283-5 ( 2013) ISSN: 1520-4383 [Electronic] United States
• PMID: 24319192 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Immunoglobulin D

Topics

• Child, Preschool
• Epistaxis (blood, diagnosis, drug therapy)
• Female
• Humans
• Immunoglobulin D
• Male
• Oral Hemorrhage (blood, diagnosis, drug therapy)
• Platelet Count
• Purpura, Thrombocytopenic, Idiopathic (blood, diagnosis)